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Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier.

Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", Nuclear Medicine Unit, University of Florence, Florence, Italy. IRCCS Don Gnocchi, Florence, Italy. Neuroradiology Unit AOU Careggi, Florence, Italy.

Journal of Alzheimer's disease : JAD. 2017;(3):697-703
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Abstract

According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [18F]Florbetapir PET uptake and Aβ1-42 cerebrospinal fluid levels were normal. Further evidences are required to establish if this association is only incidental.

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Publication Type : Case Reports

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